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4-EMC or 4-ethylmethcathinone is a designer drug of the substituted cathinones. It is a stimulant and reported entactogen.
4-EMC has the formal and systematic IUPAC name 1-(4-ethylphenyl)-2-(methylamino)propan-1-one. It has a molar mass of 191.27 grams and empirical molecular formula C12H17NO.
Cathinones like 4-EMC act as central nervous system stimulants. They tend to bind to monoamine transporters for serotonin, noradrenaline and dopamine in the brain promoting the release of these neurotransmitters and inhibiting their reuptake from the synaptic cleft.
The substituted cathinones are all related to the alkaloid cathinone found in the plant Catha edulis known as Khat. In the Middle East the leaves of this plant have been used over a period of hundreds of years. They are chewed for their stimulatory and appetite suppressing qualities and to lift mood and act as a social lubricant. Khat is a plant native to the Horn of Africa and the Arabian Peninsula. Khat is so popular in Yemen that 40 % of the country’s water supply goes towards irrigating the crop.
The substituted cathinones have emerged en force in the last decade. A wide variety of stimulants have been produced that are synthetic analogues of cathinone, the most popular and effective being 4-MMC which had widespread use in the UK in 2009.
Individual cathinones vary in their potency as inhibitors of the three monoamines. The exact pharmacological profile of 4-EMC is not known.
Almost all the cathinones are potent inhibitors at the noradrenaline (NET) transporter. This explains the strong sympathomimetic action of this class of compounds which are known to elevate the heart rate and sometimes put a strain on the heart in higher doses.
Rats trained to react only to amphetamines have been shown to react to cathinones providing clear evidence of their amphetamine like qualities.
The general structure of the cathinone series of compounds is a phenethylamine backbone with a ketone at the beta carbon and an alkyl group at the alpha carbon. 4-EMC additionally has an ethyl group substituted at the para position on the aryl ring and an N-methylation. The alkyl at the alpha carbon is a methyl group.
There are no studies in to the long term health implications of recreational use of 4-EMC. Its toxicological profile is unknown.
4-EMC is not fit for human or animal consumption.
Unverifiable reports claim it has an effects similar to but weaker than those of 4-MMC (mephedrone). The cathinone class of compounds are known to be habit forming and cause compulsive re-dosing.
Effects of 4-EMC are reported as increased wakrefulness, increased energy and alertness, increased sociability, increased talking and euphoria. Negative effects include disturbed sleep, weight loss, loss of appetite, jaw clenching, auditory and visual hallucinations, itching, moodiness and aggressiveness.
4-EMC is dangerous to mix with tramadol due to increased risk of seizure. MAOI antidepressants when used concurrently with a stimulant can lead to a hypertensive crisis.
It is considered unsafe to combine stimulants with DOx series psychedelics, NBOMes, PCP and DXM.
4-EMC should not be mixed with opioids, GHB/GBl, alcohol, cocaine, ketamine and psychadelics. Use with cannabis may induce “thought loops”.
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